Kohn Lab Papers


Y. Sun, Y. Chen, X. Ma, Y. Yuan, C. Liu, J. Kohn and J. Qian, "Mitochondria-targeted Hydroxyapatite Nanoparticles for Selective Growth Inhibition of Lung Cancer in Vitro and in Vivo", ACS App Mat Interfaces, 2016, Oct 5;8(39):25680-25690

A. Salmasi, N. Patel, G. T. Lee, R. Goyal, M. Dinizo, Y. S. Kwon, P. K. Modi, I. Faiena, J. L. Hannan, J. Kohn and I. Y. Kim, "Challenging the Paradigm of PDE-5 inhibitors use for Post-Surgical Erectile Dysfunction: Alternate Pathways and Localized Delivery System", Journal of Sexual Medicine, 2016, In Press.

J. M. Patel, A. R. Merriam, J. Kohn, C. J. Gatt and M. G. P. D. Dunn, "Negative outcomes of PLLA fiber-reinforced scaffolds in an ovine total meniscus replacement model", Tissue Eng Part A, 2016, Sep;22(17-18):1116-1125

Y. Mao, T. Hoffman, A. Johnson, Y. Duan-Arnold, A. Danilkovitch and J. Kohn, "Human cryopreserved viable amniotic membrane inhibits the growth of bacteria associated with chronic wounds", Journal of Diabetic Foot Complications, 2016, In Press.

C. Kohn, J. M. Klemens, C. Kascholke, N. S. Murthy, J. Kohn, M. Brandenburger and M. C. Hacker, "Tubular Conduits from Oligomer-Cross-Linked Hydrogels- Potential Nerve Guidance Materials", Advanced Healthcare Materials, 2016,4, 1605-1621

A. Dhaliwal, M. Brenner, P. Wolujewicz, Z. Zhang, Y. Mao, M. Batish, J. Kohn and P. V. Moghe, "Profiling Stem Cells in Three Dimensional Biomaterial Niches using High Content Image Informatics", Acta Biomat., 2016, Nov;45:98-109.

A. Chudecka-Glaz, J. Szczeblinska, A. Cymbaluk-Ploska, J. Kohn and M. El Fray, "New poly(ester-amide) copolymers modified with polyether (PEAE) for anticancer drug delivery systems", J of Microencapsulation, 2016, 1-28.

W. B. Zhang, Z. Zhang, S. Chen, L. Macri, J. Kohn and P. C. Yelick, "Mandibular jaw bone regeneration using human dental cell-seeded tyrosine-derived polycarbonate scaffolds", J of Tissue Engineeering, Part A, 2016, 22(13/14), 985-993.

L. M. Valenzuela, D. Knight and J. Kohn, "Developing a suitable model for water uptake for biodegradable polymers using small training sets", Intl J of Biomaterials, 2016, 1-11.

S. Singh, M. C. Lo, V. B. Damodaran, H. M. Kaplan, J. Kohn, J. Zahn and D. Shreiber, "Modeling the insertion mechnanics of flexible neural probes coated with sacrificial polymers for optimizing probe design", Sensors, 2016, 16, 1-18.

J. Molde, R. Soares, M. Guvendiren and J. Kohn, "Designing Biomaterials for 3D Printing", ACS Biomat Sci Engin, 2016.

L. Macri, A. J. Singer, S. A. McClain, L. Crawford, A. Prasad, J. Kohn and R. A. F. Clark, "Immediate tangential excision accelerates wound closure but does not reduce scarring of mid-dermal porcine burns", Annals of Burns and Fire Disasters, 2016, 54-61.

N. Groen, M. Guvendiren, H. Rabitz, W. J. Welsh, J. Kohn and J. de Boer, "Stepping into the omics era: opportunities and challenges for biomaterials science and engineering", Acta Biomater, 2016, 34, 133-142.

H. P. Felgueiras, N. S. Murthy, S. D. Sommerfeld, M. M. Bras, V. Migonney and J. Kohn, "Competitive adsorption of plasma proteins using quartz crystal microbalance", ACS App Mat Interfaces, 2016, 8(21), 13207-13217.

M. Ezra, J. Bushman, D. Shreiber, M. Schachner and J. Kohn, "Porous and non-porous nerve conduits: The effects of a hydrogel luminal filler with and without a neurite-promoting moeity", Tissue Eng A, 2016, 22(9-10), 818-826.

D. Bhatnagar, K. Dube, V. B. Damodaran, G. Subramanian, K. Aston, F. Halperin, M. Mao, K. Pricer, N. S. Murthy and J. Kohn, "Effects of terminal sterilization on PEG-based bioresorbable polymers used in biomedical applications", Macro Mat Engin, 2016.

F. Aydin, X. Chu, G. Uppaladadium, D. Devore, R. Goyal, N. S. Murthy, Z. Zhang, J. Kohn and M. Dutt, "Self-Assembly and Critical Aggregation Concentration Measurements of ABA Triblock Copolymers with Varying B Block Types: Model Development, Prediction and Validation", J. Phys. Chem. B, 2016, 120(15), 3666−3676.

Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP, Moghe PV. Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nature Commuications 2016


Clements BA, Bushman J, Murthy NS, Ezra M, Pastore CM, Kohn J. Design of barrier coatings on kink-resistant peripheral nerve conduits. Journal of Tissue Engineering 2016 (7) 1-14.




Lo MC, Wang S, Singh S, Damodaran VB, Kaplan HM, Kohn J, Shreiber DI, Zahn JD. Coating flexible probes with an ultra fast degrading polymer to aid in tissue insertion. Biomd Microdevices 2015 17:34


Goyal R, Macri L, Kohn J. Formulation Strategy for the Delivery of Cyclosporine A: Comparison of Two Polymeric Nanospheres. Scientific Reports 2015


Vega SL, Dhaliwal A, Arvind V, Patel PJ, Beijer NRM, Boer JD, Murthy NS, Kohn J, Moghe PV. Organizational metrics of interchromatin speckly factor domains: integrative classifier for stem cell adhesion and lineage signaling. 2015 (7) 435-446.


Chen YC, Chen RN, Jhan HJ, Lie DZ, Ho HO, Mao Y, Kohn J, Sheu MT. Development and Characterization of Acellular Extracellular Matrix Scaffolds from Porcine Menisci for Use in Cartilage Tissue Engineering. Tissue Engineering Part C: Methods. 2015 21(9) 971-986.


Kaplan HM, Mishra P, Kohn J. The overwhelming use of rat models in nerve regeneration research may compromise designs of nerve guidance conduits for humans. Journal of Materials Science: Materials in Medicine 2015 26:226




Sommerfeld SD, Zhang Z, Costache MC, Vega SL, Kohn J. Enzymatic Surface Erosion of High Tensile Strength Polycarbonates Based on Natural Phenols. Bimacromolecules 2014 15(3) 830-836


Gajowy J, Bolikal D, Kohn J, El Fray M. Synthesis and Characterixation of Fatty Acid/Amino Acid Self-Assemblies. J. Funct. Biomater. 2014 (4) 211-231.


Lewitus DY, Smith KL, Landers J, Neimark AV, Kohn J. Bioactive agarose carbon-nanotube composites are capable of manipulating brain-implant interface. J. Appl. Polym. Sci. 2014 (131) 40297


Ezra M, Bushman J, Shreiber D, Schachner M, Kohn J. Enhanced Femoral Nerve Regeneration After Tubulization with a Tyrosine-Derived Polycarbonate Terpolymer: Effects of Protein Adsorption and Independence of Conduit Porosity. Tissue Engineering Part A. 2014 20(3-4) 518-528.


Cirillo V, Clements BA, Guarino V, Bushman J, Kohn J, Ambrosio L. A comparison of the performance of mono- and bi-component electrospun conduits in a rat sciatic model. Biomaterials 2014 (32) 8970-8982




Phillip E, Murthy NS, Bolikal D, Narayanan P, Kohn J, Lavelle L, Bodnar S, Pricer K. Ethylene oxide’s role as a reactive agent during sterilization: Effects of polymer composition and device architecture. J. Biomed. Mater. Res. Part B. 2013 (101B) 532-540


Lewitus DY, Rios F, Rojas R, Kohn J. Molecular design and evaluation of biodegradable polymers using a statistical approach. J Mater Sci Mater Med 2013 (24) 2529-2535.




Chatterjee K, Kraigsley AM, Bolikal D, Kohn J, Simon CG. Gas-Foamed Scaffold Gradients for Combinatorial Screening in 3D. J. Functer. Biomat. 2012 3(1) 173-182 .


Carlson AL, Florek CA, Kim JJ, Neubauer T, Moore JC, Cohen RI, Kohn J, Grumet M, Moghe PV. Microfibrous substrate geometry as a critical trigger for organization, self-renewal and differentiation of human embryonic stem cells within synthetic 3-dimensional microenvironments. FASEB 2012 (8) 3240-3251


Shpaisman N, Sheihet L, Bushman J, Winters J, Kohn J. One-Step Synthesis of Biodegradable Curcumin-Derived Hydrogels as Potential Soft Tissue Fillers after Breast Cancer Surgery. Biomacromolecules 2012 13(8) 2279-2286.


Kifyole BE, Sheihet L, Zhang Z, Laohoo M, Kohn J, Michniak-Kohn BB. Development of paclitaxel-TyroSpheres for topical skin treatment. Journal of Controlled Release 2012 (1) 18-24.

Valenzuela LM, Zhang G, Flach CR, Murthy NS, Mendelsohn R, Michniak-Kohn B, Kohn J. Multiscale analysis of water uptake and erosion in biodegradable polyarylates. Polymer Degradation and Stability 2012 (3) 410-420


Khan IJ Murthy NS, Kohn J. Hydration-induced Phase Separation in Amphiphilic Polymer Matrices and its Influence on Voclosporin Release. J. Funct, Biomater. 2012 3(4) 745-759.


Kim, J, Magno MHR, Waters H, Doll BA, McBride S, Alvarez P, Darr A, Vasanji A, Kohn J, Hollinger JO. Tissue Engineering Part A. 2012 18(11-12) 1132-1139.


Tovar N, Murthy NS, Kohn J, Gatt C, Dunn M. ACL reconstruction using a novel hybrid scaffold composed of polyarylate fibers and collagen fibers. Journal of Biomedical Materials Research Part A. 2012 (11) 2913-2920.


Cherry JF, Carlson AL, Benarba FL, Sommerfeld SD, Verma D, Loers G, Kohn J, Schachner M, Moghe PV. Oriented, Multimeric Biointerfaces of the L1 Cell Adhesion Molecule: An Approach to Enhance Neuronal and Neural Stem Cell Functions on 2-D and 3-D Polymer Substrates. Biointerphases 2012 (22)


Luk A, Murthy NS, Wang W, Rojas R, Kohn J. Study of nanoscale structures in hydrated biomaterials using small-angle neutron scattering. Acta Biomaterialia 2012 (4) 1459-1468


Sheihet L, Garbuzenko OB, Bushman J, Gounder MK, Minko T, Kohn J. Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: IN Vivo evaluation of toxicity and efficacy in comparison with paclitaxel in Cremophor. European Journal of Pharmaceutical Sciences 2012 (3) 320-329




Lewitus, DY, Landers, J, Branch JR, Smith KL, Callegari G, Kohn J, Neimark AV. Biohybrid carbon nanotube/agarose fibers for neural tissue engineering. Advanced Functional Materials 2011 (21) 2624-2632


Joy A, Cohen DM, Luk A, Anim-Danso E, Chen C, Kohn J. Control over Surface Chemistry, Substrate Stuffness and Cell Function in a Novel Terpolymer Methacrylate Library. Langmuir 2011 (5) 1891-1899.


Valenzuela LM, Michniak B, Kohn J. Variability of water uptake studies of biomedical polymers. Jour. Appl. Poly. Sci. 2011 (121) 1311-1320


Batheja, P. Sheihet L, Kohn J, Singer AJ, Michniak-Kohn B. Topical drug delivery by a polymeric nanosphere gel: Formulation optimization and in vitro and in vivo skin distribution studies. Journal of Controlled Release. 2011 (2) 159-167.


Gubskaya AV, Bonates TO, Kholodovych V, Hammer P, Welsh WJ, Langer R, Kohn J. Logical Analysis of Data in Structure-Activity Investigation of Polymeric Gene Delivery. Macromol. Theory Simul. 2011 (20) 275-285.


Murthy NS, Bedoui F, Kifoyle BE, Iovine C, Michniak-Kohn B, Kohn J. Monitoring the viscoelastic properties of skin in liquid environments using quartz crystal microbalance. Journal of Pharmaceutical Sciences 2011 (2) 530-535




Magno MHR, Kim J, Srinivasan A, McBride S, Bolikal D, Darr A, Hollinger JO, Kohn J. Synthesis, degradation and biocompatibility of tyrosine-derived polycarbonate scaffolds. J. Mater. Chem, 2010 (20) 8885-8893


Sung HJ, Luk A, Murthy NS, Lie E, Jois M, Joy A, Bushman J, Moghe PV, Kohn J. Poly(ethylene glycol) as a sensitive regulator of cell survival fate on polymeric biomaterials: the interplay of cell adhesion and pro-oxidant signaling mechanisms. 2010 (6) 5196-5205


Costache AD, Ghosh J, Knight DD, Kohn J. Computational Methods for the Development of Polymeric Biomaterials. Adv. Eng. Mater. 2010 (12) B3-B17.


Murthy NS, Wang W, Kohn J. Microphase separation in copolymers of hydrophilic PEG blocks and hydrophobic tyrosine-derived segments using simultaneous SAXS/WAXS/DSC. Polymer 51:3978-3988, 2010


Tovar N, Bourke S, Jaffe M, Murthy NS, Kohn J, Gatt C, Dunn M. A comparison of degradable synthetic polymer fibers for anterior cruciate ligament reconstruction. J Biomed Mater Res Part A 2010; 93,738-747.


Chandra P, Lai K, Joon Sung H, Murthy NS, Kohn J. UV laser-ablated surface textures as potential regulator of cellular response. Biointerphases 5:53-59, 2010


Treiser MD, Yang EH, Gordonov S, Cohen DM, Androulakis IP, Kohn J, Chen CS, Moghe PV. Cytoskeleton-based forecasting of stem cell lineage fates. Proc Natl Acad Sci U S A 2010;107(2):610-5.


Johnson PA, Luk A, Demtchouk A, Patel H, Sung HJ, Treiser MD, Gordonov S, Sheihet L, Bolikal D, Kohn J, Moghe PV. Interplay of anionic charge, poly(ethylene glycol), and iodinated tyrosine incorporation within tyrosine-derived polycarbonates: Effects on vascular smooth muscle cell adhesion, proliferation, and motility. J Biomed Mater Res A 2010;93(2):505-14.




Joy A, Anim-Danso E, Kohn J. Simple, rapid, and highly sensitive detection of diphosgene and triphosgene by spectrophotometric methods. Talanta 2009;80(1):231-5.


Costache AD, Sheihet L, Zaveri K, Knight DD, Kohn J. Polymer-drug interactions in tyrosine-derived triblock copolymer nanospheres: a computational modeling approach. Mol Pharm 2009;6(5):1620-7.


Briggs T, Treiser MD, Holmes PF, Kohn J, Moghe PV, Arinzeh TL. Osteogenic differentiation of human mesenchymal stem cells on poly(ethylene glycol)-variant biomaterials. J Biomed Mater Res A, 2009.


Sung HJ, Roskov KE, Kohn J, Becker ML, Moghe PV. High-content profiling of cell responsiveness to graded substrates based on combinatorially variant polymers. Comb Chem High Throughput Screen 2009;12(7):646-55.


Sit PS, Kohn J. Interrelationship of micromechanics and morphology of fibroblasts adhered on different polymeric surfaces. Acta Biomater 2009;5(8):2823-31.


Liu E, Treiser MD, Patel H, Sung HJ, Roskov KE, Kohn J, Becker ML, Moghe PV. High-content profiling of cell responsiveness to graded substrates based on combinyatorially variant polymers. Comb Chem High Throughput Screen 2009;12(7):646-55.


Sung HJ, Chandra P, Treiser MD, Liu E, Iovine CP, Moghe PV, Kohn J. Synthetic polymeric substrates as potent pro-oxidant versus anti-oxidant regulators of cytoskeletal remodeling and cell apoptosis. J Cell Physiol, 2009;218(3):549-57.