The Kohn Lab

2007

Sheihet L, Piotrowska K, Dubin RA, Kohn J, Devore D. Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery. Biomacromolecules 2007;8(3):998-1003.

Kohn J, Welsh WJ, Knight D. A new approach to the rationale discovery of polymeric biomaterials. Biomaterials 2007;28:4171-4177.

Schut J, Bolikal D, Khan IJ, Pesnell A, Rege A, Rojas R, Sheihet L, Murthy NS, Kohn J. Glass transition temperature prediction of polymers through the mass-per-flexible-bond principle. Polymer 2007;48:6115-6124.

Liu E, Treiser MD, Johnson PA, Patel P, Rege A, Kohn J, Moghe PV. Quantitative biorelevant profiling of material microstructure within 3D porous scaffolds via multiphoton fluorescence microscopy. J. Biomed. Mater. Res. Part B: Appl. Biomater. 2007;82B(2):284-297.

Harris NK, Knight D, Kohn J, Welsh WJ. Biomaterials Informatics. In: Narasimham B, Mallpragada SK, editors. Combinatorial Materials Science 2007.

Gubskaya AV, Kholodovych V, Knight D, Kohn J, Welsh WJ. Prediction of fibrinogen adsorption for biodegradable polymers: Integration of molecular dynamics and surrogate modeling. Polymer 2007;48:5788-5801.

Treiser MD, Liu E, Dubin RA, Sung H-J, Kohn J, Moghe PV. Profiling cell-biomaterial interactions via cell-based fluororeporter imaging. BioTechniques 2007;43(3):361-368.

2006

Weber N, Pesnell A, Bolikal D, Zeltinger J, Kohn J. Viscoelastic properties of fibrinogen adsorbed to the surface of biomaterials used in blood-contacting medical devices. Langmuir 2006;23(6):3298-3304.

Sousa A, Sengonul M, Latour R, Kohn J, Libera M. Selective protein adsorption on a phase-separated solvent-cast polymer blend. Langmuir 2006;22(14):6286-6292.

Sousa A, Schut J, Kohn J, Libera M. Nanoscale morphological changes during hydrolytic degradation and erosion of a bioresorbable polymer. Macromolecules 2006;39(21):7306-7312.

Meechaisue C, Dubin R, Supaphol P, Hoven VP, Kohn J. Electrospun mat of tyrosine-derived polycarbonate fibers for potential use as a tissue scaffolding material. J. Biomater. Sci. Polym. Ed. 2006;17(9):1039-1056.

Auguste DT, Armes SP, Brzezinska KR, Deming TJ, Kohn J, Prud’homme RK. pH triggered release of protective poly(ethylene glycol)-b-polycation copolymers from liposomes. Biomaterials 2006;27:2599-2608.

Bailey LO, Becker ML, Stephens JS, Nathan D. Gallant, Mahoney CM, Washburn NR, Rege A, Kohn J, Amis EJ. Cellular response to phase-separated blends of tyrosine-derived polycarbonates. J. Biomed. Mat. Res. 2006;76(3):491-502.

Bae YH, Johnson PA, Florek CA, Kohn J, Moghe PV. Minute changes in composition of polymer substrates produce amplified differences in cell adhesion and motility via optimal ligand conditioning. Acta Biomaterialia 2006;2(5):473-482.

2005

Weber N, Wendel HP, Kohn J. Formation of viscoelastic protein layers on polymeric surfaces relevant to platelet adhesion. J. Biomed. Mater. Res. (Part A) 2005;72A(4):420-427.

Smith JR, Kholodovych V, Knight D, Welsh WJ, Kohn J. QSAR models for the analysis of bioresponse data from combinatorial libraries of polymers. QSAR Comb. Sci. 2005;24:99-113.

Smith JR, Kholodovych V, Knight D, Kohn J, Welsh WJ. Predicting fibrinogen adsorption to polymeric surfaces in silico: a combined method approach. Polymer 2005;46(12):4296-4306.

Sheihet L, Dubin RA, Devore D, Kohn J. Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres. Biomacromolecules 2005;6:2726-2731.

Abramson SD, Alexe G, Hammer PL, Kohn J. A computational approach to predicting cell growth on polymeric biomaterials. J. Biomed. Mat. Res 2005;73A(1):116-124.

Kohn J, Zeltinger J. Degradable, drug-eluting stents: A new frontier for the treatment of coronary artery disease. Future Drugs: Expert Review of Medical Devices 2005;2(6):667-671.

2004

Smith JR, Seyda A, Weber N, Knight D, Abramson S, Kohn J. Integration of combinatorial synthesis, rapid screening, and computational modeling in biomaterials development. Macromol. Rapid Commun. 2004;25:127–140.

Nardin C, Bolikal D, Kohn J. Nontoxic block copolymer nanospheres: Design and characterization. Langmuir 2004;20((26)):11721-5.

Kohn J. New approaches to biomaterials design. Nature Materials 2004;3:745-747.

Fang JB, Sanghi R, Kohn J, Goldman AS. Tantalum pentachloride as a coupling agent for stereohindered amide bond formation. Inorg. Chim. Acta 2004;357:2415-2426.

Weber N, Bolikal D, Bourke SL, Kohn J. Small changes in the polymer structure influence the adsorption behavior of fibrinogen on polymer surfaces: Validation of a new rapid screening technique. J. Biomed. Mater. Res. 2004;68(A):496-503.

Sousa A, Aitouchen A, Kohn J, Libera M. Quantitative EELS imaging of phase-separated morphology in poly(DTE carbonate)-poly(caprolactone) thin-film blends. Microsc. Microanal. 2004;10(Supplement S02):1426-1427.

Smith JR, Knight D, Kohn J, Rasheed K, Weber N, Kholodovych V, Welsh WJ. Using surrogate modeling in the prediction of fibrinogen adsorption onto polymer surfaces. J. Chem. Inf. Comput. Sci. 2004;44:1088-1097.

Kholodovych V, Smith JR, Knight D, Abramson S, Kohn J, Welsh WJ. Accurate Predictions of Cellular Response using QSPR: A Feasibility Test of Rational Design of Polymeric Biomaterials. Polymer 2004;45:7367-7379.

Hoven VP, Poopattanapong A, Kohn J. Acid-containing tyrosine-derived polycarbonates: Wettability and surface reactivity. Macromol. Symp. 2004;216(1):87-97.

Bourke SL, Kohn J, Dunn MG. Preliminary development of a novel resorbable synthetic polymer fiber scaffold for anterior cruciate ligament reconstruction. Tissue Engineering 2004;10(1):43-52.

Zeltinger J, Schmid E, Brandom D, Bolikal D, Pesnell A, Kohn J. Advances in the development of coronary stents. Biomaterials Forum (Official Newsletter of the Society for Biomaterials) 2004;26(1):8-24.

Bourke SL, Kohn J, Dunn MG. Preliminary development of a novel resorbable synthetic polymer fiber scaffold for anterior cruciate ligament reconstruction. Tissue Engineering 2004;10(1):43-52.

Sharma RI, Kohn J, Moghe PV. Poly(ethylene glycol) enhances cell motility on protein-based poly(ethylene glycol)-polycarbonate substrates: A mechanism for cell-guided ligand remodeling. J. Biomed. Mater. Res., Part A 2004;69A(1):114-123.

2003

Bourke SL, Kohn J. Polymers derived from the amino acid L-tyrosine: Polycarbonates, polyarylates and copolymers with poly(ethylene glycol). Adv. Drug Del. Rev. 2003;55(4):447-466.

Bourke SL, Al-Khalili M, Briggs T, Michniak BB, Kohn J, Poole-Warren LA. A photo-crosslinked poly(vinyl alcohol) hydrogel growth factor release vehicle for wound healing applications. AAPS PharmSci. 2003;5 article 33(4):article 33.

Auguste DT, Prud’homme RK, Ahl PL, Meers P, Kohn J. Association of hydrophobically modified poly(ethylene glycol) with fusogenic liposomes. Biochim. Biophys. Acta 2003;1616:184-195.

2002

Yang B-S, Lal J, Mihailescu M, Monkenbusch M, Richter D, Huang JS, Kohn J, Russel WB, Prud’homme RK. Neutron spin-echo study of dynamics of hydrophobically modified polymer-doped surfactant bilayers. Langmuir 2002;18:6-13.

Schachter DM, Kohn J. A synthetic polymer matrix for the delayed or pulsatile release of water-soluble peptides. J. Control. Rel. 2002;78:143-153.

Perez-Luna VH, Kohn J, Graham DJ, Ratner BD. Poly(desaminotyrosyl-tyrosine carbonate ethyl ester) studied by XPS. Surf. Sci. Spectra 2002;9:6-11.

d'Acunzo F, Kohn J. Alternating multiblock amphiphilic copolymers of PEG and tyrosine-derived diphenols. I. Synthesis and characterization. Macromolecules 2002;35:9360-9365.

d'Acunzo F, Le TQ, Kohn J. Alternating multiblock amphiphilic copolymers of PEG and tyrosine-derived diphenols. II. Self-assembly in aqueous solution and at hydrophobic surfaces. Macromolecules 2002;35:9366-9371.

Jaffe M, Pai V, Ophir Z, Wu J, Kohn J. Process-structure-property relationships of erodable polymeric biomaterials, I: Poly(desaminotyrosyl arylates). Pol. Adv. Tech. 2002;13:926-937.

2001

Yang B-S, Lal J, Kohn J, Huang JS, Russel WB, Prud'homme RK. Interaction of surfactant lamellar phase and a strictly alternating comb-graft amphiphilic polymer based on PEG. Langmuir 2001;17(21):6692-6698.

Hwang ML, Prud'homme RK, Kohn J, Thomas JL. Stabilization of phosphatidylserine/phosphatidylethanolamine liposomes with hydrophilic polymers having multiple "Sticky Feet". Langmuir 2001;17(25):7713-7716.

Suarez N, Brocchini S, Kohn J. Study of relaxation mechanisms in structurally related biomaterials by thermally stimulated depolarization currents. Polymer 2001;42(21):8671-8680.

Ryan PL, Foty RA, Kohn J, Steinberg M. Tissue spreading on implantable substrates is a competitive outcome of cell-cell vs. cell-substratum adhesivity. Proc. Natl. Acad. Sci. 2001;98(8):4323-4327.

2000

Tangpasuthadol V, Pendharkar SM, Kohn J. Hydrolytic degradation of tyrosine-derived polycarbonates, a class of new biomaterials. Part I: Study of model compounds. Biomaterials 2000;21:2371-2378.

Tangpasuthadol V, Pendharkar SM, Peterson RC, Kohn J. Hydrolytic degradation of tyrosine-derived polycarbonates, a class of new biomaterials. Part II: 3-yr study of polymeric devices. Biomaterials 2000;21:2379-2387.

Belu AM, Brocchini S, Kohn J, Ratner BD. Characterization of combinatorially designed polyarylates by time-of-flight secondary ion mass spectrometry. Rapid Commun. Mass Spectrom. 2000;14:564-571.

Tziampazis E, Kohn J, Moghe PV. PEG-variant biomaterials as selectively adhesive protein templates: Model surfaces for controlled cell adhesion and migration. Biomaterials 2000;21:511-520.

Hooper KA, Nickolas TL, Yurkow EJ, Kohn J, Laskin DL. Characterization of the inflammatory response to biomaterials using a rodent air pouch. J. Biomed. Mater. Res. 2000;50:365-374.

1999

Yu C, Mielewczyk SS, Breslauer KJ, Kohn J. Tyrosine-PEG-derived poly(ether carbonate)s as new biomaterials. Part II: Study of inverse temperature transitions. Biomaterials 1999;20(3):265-272.

Yu C, Kohn J. Tyrosine-PEG-derived poly(ether carbonate)s as new biomaterials. Part I: Synthesis and Evaluation. Biomaterials 1999;20(3):253-264.

Heitz C, Prud'homme RK, Kohn J. A new, strictly alternating, comb-like amphiphilic polymer based on PEG: Part 2: Associative behavior of a high molecular weight sample and interaction with SDS. Macromolecules 1999;32(20):6658 - 6667.

Heitz C, Pendharkar S, Prud'homme RK, Kohn J. A new, strictly alternating, comb-like amphiphilic polymer based on PEG: Part 1: Synthesis and associative behavior of a low molecular weight sample. Macromolecules 1999;32(20):6652 - 6657.

Puma M, Suarez N, Kohn J. Conductivity and high-temperature relaxation of tyrosine-derived polyarylates measured with thermal stimulated currents. J. Polym. Sci. Part B: Polym. Phys. 1999;37:3504-3511.

James K, Levene H, Parsons JR, Kohn J. Small changes in polymer chemistry have a large effect on the bone-implant interface: Evaluation of a series of degradable tyrosine-derived polycarbonates in bone defects. Biomaterials 1999;20(23/24):2203-2212.

1998

Brocchini S, James K, Tangpasuthadol V, Kohn J. Structure-property correlations in a combinatorial library of degradable biomaterials. J. Biomed. Mater. Res. 1998;42:66-75.

Suarez N, Brocchini S, Kohn J. The study of water uptake in degradable polymers by thermally stimulated depolarization currents. Biomaterials 1998;19:2347-2356.

Lhommeau C, Levene H, Abramson S, Kohn J. Preparation of highly interconnected porous, tyrosine-derived polycarbonate scaffolds. Tissue Engineering 1998;4(4):468.

Hooper KA, Macon ND, Kohn J. Comparative histological evaluation of new tyrosine-derived polymers and poly(L-lactic acid) as a function of polymer degradation. J. Biomed. Mater. Res. 1998;41(3):443-454.

1997

Poiani GJ, Kemnitzer JE, Fox JD, Tozzi CA, Kohn J, Riley DJ. Polymeric carrier of proline analogue with antifibrotic effect in pulmonary vascular remodeling. Amer. J. Respir. Crit. Care Med. 1997;155(4):1384-1390.

Hooper KA, Cox JD, Kohn J. Comparison of the effect of ethylene oxide and γ-irradiation on selected tyrosine-derived polycarbonates and poly(L-lactic acid). J. Appl. Polym. Sci. 1997;63(11):1499-1510.

Greco MJ, Kemnitzer JE, Fox JD, Jin K. Choe, Kohn J, Riley DJ, Poiani GJ. Polymer of proline analogue with sustained antifibrotic activity in lung fibrosis. Amer. J. Respir. Crit. Care Med. 1997;155(4):1391-1397. -

Brocchini S, James K, Tangpasuthadol V, Kohn J. A combinatorial approach for polymer design. J. Amer. Chem. Soc. 1997;119(19):4553-4554.

Tangpasuthadol V, Shefer A, Yu C, Zhou J, Kohn J. Thermal properties and enthalpy relaxations of tyrosine-derived polyarylates. J. Appl. Polym. Sci. 1997;63(11):1441-1448.

Suarez N, Laredo E, Bello A, Kohn J. Molecular relaxation mechanisms of tyrosine-derived polycarbonates by thermally stimulated depolarization currents. J. Appl. Polym. Sci. 1997;63(11):1457-1466.

Ramanujachary KV, Tong X, Lu Y, Kohn J, Greenblatt M. Lithium ionic conductivity in poly(ether urethanes) derived from poly(ethylene glycol) and lysine ethyl ester. J. Appl. Polym. Sci. 1997;63(11):1449-1456.

Perez-Luna VH, Hooper KA, Kohn J, Ratner BD. Surface characterization of tyrosine-derived polycarbonates. J. Appl. Polym. Sci. 1997;63(11):1467-1479.